I'm using WordPress 3.0.1 on Windows 2003 32-bit running PHP 5.x with fastcgi on IIS6.
I am using the Contact Form 7 plugin for WordPress, and getting an HTTP 500 error on submit. I am also getting HTTP 500 errors sending the test mail using the Configure-Smtp plugin. I've narrowed it down to the wp_mail
line in both cases.
I can create a .php page in the same website and send an email using the php mail function, so I'm pretty sure PHP, IIS, and SMTP are all functioning.
Firebug does not give me much in the way of useful info - I can paste the post and response headers if it would help.