As Explosion Pills said, if you're looking for cross–site exploits, you're probably best to either find one that's already been written or someone who can write one for you.
Anyway, to answer the question, regular expressions are not appropriate for parsing markup. If you have an HTML parser (client side is easy, server a little more difficult) you could insert the text as the innerHTML of an new element, then see if there are any child elements:
function mightBeMarkup(s) {
var d = document.createElement('div');
d.innerHTML = s;
return !!(d.getElementsByTagName('*').length);
}
Of course there still might be markup in the text, just that it's invalid so doesn't create elements. But combined with some other text, it might be valid markup.